Technical Session - 3

Title:            The formation and characterization of the supramolecular hydrogel based on Poly (ethylene glycol) methyl ther- a-cyclodextrin inclusion complex conjugated with folic acid
Authors:       Bich-Tram Truong Le
Abstract:     In this work, folic acid (FA) has been conjugated with the a-Cyclodextrin (a-CD) and then used for constructing novel supramolecular hydrogels together with Poly(ethylene glycol) methyl ether (MPEG) in aqueous solutions. This strategy can result in the formation of bioactive supramolecular hydrogels with multifunctional characteristics. Nuclear magnetic resonance (1H NMR), and Fourier-transform infrared (FT-IR) spectroscopy were applied for the structural analyses of the functionalized cyclodextrin with FA. The formation of the supramolecular hydrogel was investigated using wide angle X-ray diffraction (WAXD) and FT-IR for a- CD-FA, MPEG, and freeze-dried hydrogel sample which formed in situ from 2 wt % of MPEG and 7 wt % of a- CD-FA.

Keywords:  Folic acid, supramolecular hydrogel, inclusion complex, a-Cyclodextrin, Poly(ethylene glycol) methyl ether.
Pages:        158-161

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