ISSN 2319-5347, ISI Impact Factor: 0.763

VOLUME 03 NO. 01 JANUARY 2015:

Title:          Screening for Immunomodulatory activity of fermented Ophiocordyceps Sinensis
Authors:    Minh-Hiep Dinh, The-Phuong Nguyen, Thu Huynh, Binh-Nguyen Truong
Abstract: Ophiocordyceps sinensis, a well-known Chinese herbal medicine, has been demonstrated to possess a myriad of biological compounds and effects. In this study, we evaluated the immunomodulatory activities of fermented O. sinensis extracts on human peripheral blood mononuclear cells (PBMC). The extracts were tested in the PBMC collected from three healthy volunteers with normal leukocyte cell index. At the concentrations of 50, 100 and 200 µg/ml, the BuOH and CPS significantly increased the proliferation of PBMC (%) to 84.55 ± 21.85, 120.35 ± 43.07, 21.98 ± 9.75 and 20.14 ± 8.15, 16.69 ± 5.89, and 21.25 ± 11.75, respectively (p<0.05). Furthermore, water extract at 100 µg/ml showed a proliferation of was 16.99 ± 16.87 % (p<0.05). The result indicated that the BuOH at 100 µg/ml exhibited the highest proliferation rate. Besides, EtOH (only at the concentration of 200 µg/ml), PE and EtOAc also exhibited the inhibitory effects on the human PBMC. In conclusion, these data revealed the immuno-enhancing ability of O. sinensis, suggesting that further studies on in vivo models would be necessary.

Keywords:   Extract, Immunomodulatory Activity, PBMC, Ophiocordyceps Sinensis
Pages:          40-43

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